Altered lipid profile and cardiovascular risk in patients with subclinical hypothyroidism.
DOI:
https://doi.org/10.19230/jonnpr.2016.1.2.970Keywords:
Thyroid, cholesterol, subclinical hypothyroidism, Cardiovascular risk, Cardiovascular disease risk factors.Abstract
Summary: Several studies have shown a theoretical relationship between pro-atherogenic lipid profile and subclinical hypothyroidism,
which could rise if the latter could condition increased cardiovascular risk.
Objective: To establish the association between subclinical hypothyroidism and parameters that can determine an increased
cardiovascular risk or an unfavorable lipid profile.
Methods: Cross-sectional study conducted in the province of Albacete in January 2012 in patients with subclinical hypothyroidism.
Laboratory parameters, physical examination and medical history were collected. Subsequently, cardiovascular risk was estimated by
Framingham.
Results: No increase in cardiovascular risk factors was found. The value of TSH in patients with pathological LDL-cholesterol was
increased disease without statistical significance (p = 0.412, 95% CI [-0.45, - 0.179]). No relationship between TSH and total
cholesterol (p = 0.641), HDL (p = 0.931) or LDL (p = 0.747) was found. Only, association with a pathological level of triglycerides (p =
0.0004) was detected.
Conclusions: There is no relationship between subclinical hypothyroidism and increased cardiovascular risk, increased cardiovascular
risk factors or unfavorable lipid profile except for pathological levels of triglycerides.
Downloads
References
McDermott MT, Ridgway EC. Subclinical hypothyroidism is mild thyroid failure and should be treated. J Clin
Endocrinol Metab. 2001;86:4585-90.
Gharib H, Tuttle RM, Baskin HJ, Fish LH, Singer PA, McDermott MT. Subclinical thyroid dysfunction: a joint
statement on management from the American Association of Clinical Endocrinologists, the American Thyroid
Association, and the Endocrine Society. J Clin Endocrinol Metab. 2005;90:581-5.
McDermott MT. In the clinic. Hypothyroidism. Ann Intern Med. 2009;15:ITC61.
Del Campo del Campo JM, López-Torres Hidalgo J, Requena Gallego M, Escobar Rabadán F, Díaz Torres C,
Muñoz Sánchez-Villacañas. Perfil lipídico y síntomas en pacientes con hipotiroidismo subclínico. Medicina de
Familia. feb. 2004.5:35-40.
Türemen E, Çetinarslan B,
in subclinical hypothyroidism due to autoimmune thyroiditis. Endocrine J 2011; 58, 349-354.
Owecki M, Michalak A, Nikisch E. Przegl Lek. Subclinical hypothyroidism influences ventricular repolarization
measured by QTc. Przegl Lek, 2006;63:185–187.
Rodondi N, Newman AB, Vittinghoff E. Clinical hypothyroidism and the risk of heart failure, other cardiovascular
events, and death. Arch Intern Med. 2005;165(21):2460–2466.
Caraccio N, Ferrannini E, Monzani F. Lipoprotein profile in subclinical hypothyroidism: response to levothyroxine
replacement, a randomized placebo-controlled study. J Clin Endocrinol Metab 2002;87:1533-1538.
Lee YK, Kim JE, Oh HJ, Park KS, Kim SK, Park SW et. al. Serum TSH Level in Healthy Koreans and the
association of TSH with serum lipid concentration and metabolic syndrome. Korean J Intern Med 2011;26:432-
Asvold BO, Vatten LJ, Nilsen TIL, Bjøro T. The association between TSH within the reference range and serum
lipid concentrations in a population-based study. The HUNT Study. Eur J Endocrinol 2007;156; 181–186.
Kung AWC, Pang RWC, Janus ED. Elevated serum lipoprotein (a) in subclinical hypothyroidism. Clin Endocrinol,
; 43: 445-9.
Christ-Crain M, Meier C, Guglielmetti M. Elevated C-reactive protein and homocysteine values: cardiovascular
risk factors in hypothyroidism? A cross-sectional and a doubleblind, placebo-controlled trial. Atherosclerosis.
; 166:379–386.
Faber J, Petersen L, Wiinberg N. Hemodynamic changes after levothyroxine treatment in subclinical
hypothyroidism. Thyroid. 2002;12:319–324.
Monzani F, Dardano A, Caraccio N.Does treating subclinical hypothyroidism improve markers of cardiovascular
risk?. Treat Endocrinol. 2006;5:65–81.
Additional Files
Published
Issue
Section
License
All accepted originals remain the property of JONNPR. In the event of publication, the authors exclusively transfer their rights of reproduction, distribution, translation and public communication (by any sound, audiovisual or electronic medium or format) of their work. To do so, the authors shall sign a letter transferring these rights when sending the paper via the online manuscript management system.
The articles published in the journal are freely used under the terms of the Creative Commons BY NC SA license, therefore.
You are free to:
Share — copy and redistribute the material in any medium or format
Adapt — remix, transform, and build upon the material
The licensor cannot revoke these freedoms as long as you follow the license terms.
Under the following terms:
Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
NonCommercial — You may not use the material for commercial purposes.
ShareAlike — If you remix, transform, or build upon the material, you must distribute your contributions under the same license as the original.
No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License
