Benefits and damages of Screening. Overdiagnosis and anticipatory medicine

Authors

  • Antonio Zarazaga Jefe de Sección en Servicio de Cirugía General y de Urgencia del Hospital Universitario La Paz, hasta 2013. Profesor colaborador, Departamento de Cirugía, Universidad Autónoma de Madrid, España
  • Ángeles Franco-López Jefa de los Servicios de Radiología de los hospitales de Vinalopó y Torrevieja. AcProfesora de Universidad por ANECA, Alicante, España
  • Jesús M. Culebras De la Real Academia de Medicina de Valladolid y del IBIOMED, Universidad de León. Miembro de Número y de Honor de la Academia Española de Nutrición y Dietética Académico Asociado al Instituto de España. AcProfesor Titular de Cirugía. Director, Journal of Negative & No Positive Results. Director Emérito de NUTRICION HOSPITALARIA, España

DOI:

https://doi.org/10.19230/jonnpr.3299

Abstract

Treatment of breast cancer has changed markedly since the publication of papers recommending screening programs for early diagnosis. Posterior reevaluations demonstrated mistakes; advances in  oncological therapy and better knowledge of the problem have demonstrated the doubtful efficacy of  these procedures which, on the other hand have also side effects with risk of overdiagnosis and  overtreatment. Misinformation confuses patients. This procedure has been recommended by many  institutions without explaining possible important risks. It is very easy to promote mammograms if the  majority feel that it reduces risk of breast cancer and saves many lives. Unfortunately this is not the case. At present there are many people against screening who are recommending explicit and precise explanations of the procedure as well as of the importance of physical examination. Women must discuss with their physicians their own risk, possible benefits and eventual risks and damages of mammograms and they must take informed decision about screening. Women should be classified in those with potential  benefits of mammograms and those with more risks than benefits. A program which does not  offer clearly more benefits than risks cannot be implemented by Public Heath institutions. Complete and  impartial information, adequate attention and prevention of overdiagnosis and overtreatment would be  the best option.

 

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References

Sackett DL, Holland WW. Controversy in the detection of disease. 1975 Lancet; 23:357-359

Sackett DL. The arrogance of preventive medicine. 2002CMAJ; 167 (4) 363-364.

Nyström L, Rutqvist LE, Wall S, et al. Breast cancer screening with mammography: overview of Swedish randomised trials. Lancet 1993;341:973–8.

Gøtzsche PC, Nielsen M. Screening for breast cancer with mammography. Cochrane Database Syst Rev 2009;4:CD001877

Bleyer A, Welch G. Effect of Three Decades of Screening Mammography on Breast-Cancer Incidence. N Engl J Med 2012;367:1998-2005. DOI: 10.1056/NEJMoa1206809

NBCC. National Breast Cancer Coalition. Mammography for Breast Cancer Screening: Harm/Benefit Analysis. 2011.Doi: www.breastcancerdeadline2020.org/breast-cancerinformation/breast-cancer-information-and- positions/mammography-for-breastcancer.pdf

Gøtzsche PC, Jørgensen KJ. Screening for breast cancer with mammography. Cochrane Database Syst Rev. 2013;6:CD001877.

Gøtzsche PC. Mammography screening: truth, lies and controversy. London: Radcliffe Publishing; 2012.

Jørgensen KJ, Keen JD, Gøtzsche PC. Is mammographic screening justifiable considering its substantial overdiagnosis rate and minor effect on mortality? Radiology 2011;260:621-6.

Biller-Andorno N, Jüni P. Abolishing mammography screening programs? A view from the Swiss Medical Board. N Engl J Med. 2014;370:1965-1967.

Gøtzsche PC , Harting OJ, Nielsen M, et al. La mamografía como método de cribado para detectar el cáncer de mama. Centro Nórdico Cochrane 2012.https://nordic.cochrane.org/sites/nordic.cochrane.org/files/public/uploads/images/mammography/mamo grafia-es.pdf.

Prasad V, Lenzer J, Newman DH. Why cancer screening has never been shown to "save lives"—and what we can do about it. BMJ. 2016;352:h6080.

Gigerenzer G. Full disclosure about cancer screening. BMJ. 2016;352:h6967

Published

2020-01-30