Applications of therapeutic fasting and its use in nutritional and dietary consultancies. Presentation of successful and nonsuccessful cases in patients with inflammatory disease
DOI:
https://doi.org/10.19230/jonnpr.3012Keywords:
fasting, intermittent fasting, caloric restriction, lupus, arthrosis, arthritisAbstract
The use of fasting has a long history, and in recent years has regained popularity, appearing in a number of current medical studies. In respect of nutrition the practice has been subject to only limited usage, although it has a great number of possible benefits for the nutritionist-dietician. This study evaluates the efficacy of fasting in clinical practice where conventional nutritional procedures have proven insufficient. Two cases are presented:
Patient 1 - suffered from systemic lupus erythematosus and Sjogren's syndrome. Symptoms were; unremitting pain and itching that could not be alleviated by steroids nor antihistamines, generalised inflammation and erythema in the whole body. Treatment of fasting combined with a controlled diet had positive results that completely eliminated erythema, itch and reduced the weight gain caused by corticoids. Patient is currently controlling outbreaks with regular periods of fasting combined with the prescribed dietary regime.
Patient 2 – a possible diagnosis of arthrosis or psoriatic arthritis with pain and paresthesia in both hands caused by inflammation of the first interphalangeal joint of the index finger. Pain and fatigue that did not improve with treatment. Autonomous fasting regime was unsuccessful. An exact diagnosis has still not been made and although a new dietary regime was successful in controlling pain, fasting was not successful in controlling the condition. This proved the necessity of continued research of the use of fasting in this area, in which fasting has proven to be beneficial not only in the case of obesity, but also other conditions such as hypertension, type 2 diabetes, rheumatoid arthritis, depression and cancer.
Downloads
References
Kerndt PR, Naughton JL, Driscoll CE, Loxterkamp DA. Fasting: the history, pathophysiology and complications. West J Med. 1982;137(5):379-99.
Wilhelmi de Toledo F1, et al. Fasting therapy - an expert panel update of the 2002 consensus guidelines. Forsch Komplementmed. 2013; 20(6): 434-43.
Le Maho, et al. Nutrient reserve dynamics and energetics during long- term fasting in the king penguin (Aptenodytes patagonicus). Journal of zoology. 2009; 234(1): 1-12.
Hursting SD1, Smith SM, Lashinger LM, Harvey AE, Perkins SN. Calories and carcinogenesis: lessons learned from 30 years of calorie restriction research. Carcinogenesis. 2010; 31(1): 83-9.
A Periodic Diet that Mimics Fasting Promotes Multi-System Regeneration, Enhanced Cognitive Performance, and Health span. Cell Metab. 2015; 22(1): 86-99.
Patterson RE, Sears DD. Metabolic Effects of Intermittent Fasting. Annu Rev Nutr. 2017; 37: 371-393.
Wilhelmi de Toledo F, Grundler F, Bergouignan A, Drinda S, Michalsen A. Safety, health improvement and well-being during a 4 to 21-day fasting period in an observational study including 1422 subjects. PLoS One. 2019 Jan 2;14(1):e0209353.
Raffaghello L, Lee C, Safdie FM, Wei M, Madia F, Bianchi G, et al. Starvationdependent differential stress resistance protects normal but not cancer cells against high-dose chemotherapy. Proceedings of the National Academy of Sciences. 2008; 105(24):8215–20.
Lopez-Otın C, Galluzzi L, Freije JMP, Madeo F, Kroemer G. Metabolic Control of Longevity. Cell. 2016;166(4):802–21.
Alirezaei M, Kemball CC, Flynn CT, Wood MR, Whitton JL, Kiosses WB. Short-term fasting induces profound neuronal autophagy. Autophagy. 2010; 6(6):702–10.
Fontana L, Partridge L. Promoting Health and Longevity through Diet: From Model Organisms to Humans. Cell. 2015; 161(1):106–18.
Lee C, Raffaghello L, Longo VD. Starvation, detoxification, and multidrug resistance in cancer therapy. Drug Resistance Updates. 2012; 15(1):114–22.
Remely M, Hippe B, Geretschlaeger I, Stegmayer S, Hoefinger I, Haslberger A. Increased gut microbiota diversity and abundance of Faecalibacterium prausnitzii and Akkermansia after fasting: a pilot study. Wiener klinische Wochenschrift. 2015; 127(9–10):394–8.
Habold C, Reichardt F, Foltzer-Jourdainne C, Lignot J-H. Morphological changes of the rat intestinal lining in relation to body stores depletion during fasting and after refeeding. Pflugers Archiv- European Journal of Physiology. 2007; 455(2):323–32.
Mattson MP, Moehl K, Ghena N, Schmaedick M, Cheng A. Intermittent metabolic switching, neuroplasticity and brain health. Nature Reviews Neuroscience. 2018.
Fontana L, Partridge L, Longo VD. Dietary Restriction, Growth Factors and Aging: from yeast to humans. Science (New York, NY). 2010; 328(5976):321–6.
Molina Jiménez et al. Hematologic Changes After A Mediterranean Diet With Semi-Fasting Intervention For Weight Loss: A Short Term 6- Week Trial. Int J Recent Sci Res. 2018; 9(5): 27085-27089.
Andrews J, Kashiwagi A, Verso MA, Vasquez B, Howard BV, Foley JE. Effects of four day fast on triglyceride mobilization in human adipocytes. Int J Obes.1984; 8(4): 355-63.
Goldhamer AC: Initial cost of care results in medically supervised water-only fasting for treating high blood pressure and diabetes. J Altern Complement Med. 2002; 8: 696-697.
Amatruda JM, Richeson JF, Welle SL, Brodows RG, Lockwood DH. The safety and efficacy of a controlled low-energy (‘verylow-calorie’) diet in thetreatment of non-insulin dependent diabetes and obesity. Arch Intern Med. 1988; 148(4): 873-7.
Fond GL, Macgregor A, Leboyer M, Michalsen A. Fasting in mood disorders: neurobiology and effectiveness. A review of the literature. Psychiatry Res. 2013; 209(3):253-8. Epub 2013.
Müller H, de Toledo FW, Resch KL. Fasting followed by vegetarian diet in patients with rheumatoid arthritis: a systematic review. Scand J Rheumatol. 2001;30(1):1-10.
Sebastian Brandhorst and Valter D. Longo. Fasting and Caloric Restriction in Cancer Prevention and Treatment. Recent Results Cancer Res. 2016;207:241-66.
Additional Files
Published
Issue
Section
License
All accepted originals remain the property of JONNPR. In the event of publication, the authors exclusively transfer their rights of reproduction, distribution, translation and public communication (by any sound, audiovisual or electronic medium or format) of their work. To do so, the authors shall sign a letter transferring these rights when sending the paper via the online manuscript management system.
The articles published in the journal are freely used under the terms of the Creative Commons BY NC SA license, therefore.
You are free to:
Share — copy and redistribute the material in any medium or format
Adapt — remix, transform, and build upon the material
The licensor cannot revoke these freedoms as long as you follow the license terms.
Under the following terms:
Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
NonCommercial — You may not use the material for commercial purposes.
ShareAlike — If you remix, transform, or build upon the material, you must distribute your contributions under the same license as the original.
No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License
