Effect of nutritional recovery on the serum concentration of lipid peroxide in children with primary and severe protein energy malnutrition.
DOI:
https://doi.org/10.19230/jonnpr.2016.1.4.1048Keywords:
Severe malnutrition, lipoperoxides, nutritional recoveryAbstract
Objective. The purpose is to show lipid peroxide’s serum concentration trend during a four-week nutritional recovery period in children with primary and severe protein energy malnutrition (PEM).
Methods. In a clinical intervention 12 primarily and severely malnourished children (three to 48 months of age) were included. Dependent variable: Serum lipid peroxide (LPO) concentration (nmol/mL). Independent variables: non lactose starting infant formula
(200 kcal/kg/d and proteins 4 g/kg/d). Age, sex, nutritional recovery, weight/age, length/age and weight/length indices calculated and expressed as Z scores were included. For statistical analysis a repeated measure ANOVA model was applied. A non-parametric Mann Whitney U-Test was used to compare groups. Null hypothesis was rejected with a p value
Downloads
References
Augusto RL, Isaac AR, Silva-Júnior II, Santana DF, Ferreira DJ, Lagranha CJ, et al. Fighting Oxidative Stress:
Increased Resistance of Male Rat Cerebellum at Weaning Induced by Low Omega 6/Omega 3 Ratio in a Protein-
Deficient Diet. Cerebellum. 2016 Mar 22. [Epub ahead of print]. DOI:10.1007/s12311-016-0773-1
Bonatto F, Polydoro M, Andrades MÉ, Júnior MLCDF, Dal-Pizzol F, Rotta LN, et al. Effects of maternal protein
malnutrition on oxidative markers in the young rat cortex and cerebellum. Neurosci Lett. 2006; 406:281–4.
Hazell AS, Faim S, Wertheimer G, Silva VR, Marques CS. The impact of oxidative stress in thiamine deficiency: a
multifactorial targeting issue. Neurochem Int. 2013; 62:796–802
Feoli AM, Siqueira IR, Almeida L, Tramontina AC, Vanzella C, Sbaraini S, et al. Effects of protein malnutrition on
oxidative status in rat brain. Nutrition. 2006; 22:160–5.
Kuhnt K, Wagner A, Kraft J, Basu S, Jahreis G. Dietary supplementation with 11trans- and 12trans- 18:1 and
oxidative stress in humans. Am J Clin Nutr 2006; 84: 891-898.
Tatli M, Guzel A, Kizil G, Kavak V, Yavuz M, Kizil M. Comparison of the effects of maternal protein malnutrition
and intrauterine growth restriction on redox state of central nervous system in offspring rats. Brain Res. 2007;
:21–30.
Ramdath DD, Golden MH 1993 Elevated glutathione S-Transferase activity in erythrocytes from malnourished
children. Eur J Clin Nutr. 1993; 47: 658-665.
Fechner A, Bohme C, Gromer S, Funk M, Schirmer R, Becker K. Antioxidant status and nitric oxide in the
malnutrition syndrome kwashiorkor. Pediatr Res 2001; 49: 237-43.
Biolo G, Antonione R, De Cicco M. Glutathione metabolism in sepsis. Crit Care Med 2007; 35: S591-S595.
Becker K, Pons-Kuhnemann J, Fechner A, Funk M, Gromer S, Gross HJ, Grünert A, Schirmer RH. Effects of
antioxidants on glutathione levels and clinical recovery from the malnutrition syndrome kwashiorkor--a pilot study.
Redox Rep 2005; 10: 215-26.
Squali-Houssaini FZ, Arnaud J, Richard MJ, Renversez JC, Favier A. Evaluation of oxidative stress and
antioxidant defenses in malnourished Moroccan children. Ann Nutr Metab 1997; 41: 149-59.
Squali Houssaini FZ, Foulon T, Payen N, Iraqi MR, Arnaud J, Groslambert P. Plasma fatty acid status in
Moroccan children: Increased lipid per-oxidation and impaired polyunsaturated fatty acid metabolism in proteincalorie
malnutrition. Biomed Pharmacother 2001; 55: 155-62.
Mortensen A, Hasselholt S, Tveden-Nyborg P, Lykkesfeldt J. Guinea pig ascorbate status predicts
tetrahydrobiopterin plasma concentration and oxidation ratio in vivo. Nutr Res. 2013; 33:859-67.
Mayne ST. Antioxidant nutrients and chronic disease: use of biomarkers of exposure and oxidative stress status
in epidemiologic research. J Nutr 2003; 133: 933S-940S.
Khaled MA, Kabir MD, Mahalanabi D. Effect of protein energy supplementation on oxidative stress in
malnourished children. Nutr Res 1995; 15: 1099-1104.
Sharda B. Free radicals: emerging challenge in environmental health research in childhood and neonatal
disorders. Int J Environ Res Public Health 2006; 3: 286-91
Sive AA, Subotzky EF, Malan H, Dempster WS, Heese HD. Red blood cell antioxidant enzyme concentrations in
kwashiorkor and marasmus. Ann Trop Paediatr 1993; 13: 33-38.
Thomas JA. Oxidant defense in oxidative and nitrosative stress. In: Shils ME, Shike Ross AC, Caballero B,
Cousins RJ. Modern Nutrition n in Health and Disease. 10th Ed. Lippincott Williams & Wilkins, Philadelphia, PA,
, pp. 685-694.
Tatli MM, Vural H, Koc A, Kosecik M, Atas A. Altered antioxidant status and increased lipid peroxidation in
marasmic children. Pediatr Int 2000; 42: 289-92.
Partadiredja G, Worrall S, Simpson R, Bedi KS. Pre-weaning undernutrition alters the expression levels of
reactive oxygen species enzymes but not their activity levels or lipid peroxidation in the rat brain. Brain Res.
; 1222:69–78.
Akkus I, Saglam NI, Caglayan O, Vural H, Kalak S, Sa
peroxidation and antioxidant defense systems of patients with coronary artery disease (CAD) documented by
angiography. Clin Chim Acta 1996; 244: 173-80
Golden MHN, Ramdath DC. Free radical in the pathogenesis of kwashiorkor. Proc Nutr Soc 1987; 46: 53-86.
Munday R, Winterbourn CC. Reduced glutathione in combination with superoxide dismutase as an important
biological antioxidant defense mechanism. Biochem Pharmacol 1989; 38: 4349-4365.
Jahoor F, Badaloo A, Reid M, Forrester T. Protein metabolism in severe childhood malnutrition. Ann Trop
Paediatr 2008; 28: 87-101.
Lenhartz H, Ndasi R, Anninos A, Bötticher D, Mayatepek E, Tetanye E, Leichsenring M. The clinical manifestation
of the kwashiorkor syndrome is related to increased lipid per-oxidation. J Pediatr 1998; 132: 879-81.
Hu FB, Manson JE, Willett WC. Types of dietary fat and risk of coronary heart disease: a critical review. J Am Coll
Nutr 2001; 20: 5-19
Mozaffarian D, Pischon T, Hankinson SE, Rifai N, Joshipura K, Willett WC, Rimm EB. Dietary intake of trans fatty
acids and systematic inflammation in women. Am J Clin Nutr 2004; 79: 606-12.
Lopez-Garcia E, Schulze MB, Meigs JB, Manson JE, Rifai N, Stampfer MJ, Willett WC, Hu FB. Consumption of
trans fatty acids is related to plasma biomarkers of inflammation and endothelial dysfunction. J Nutr 2005; 135:
-66.
Salmeron J, Hu FB, Manson JE, Stampfer MJ, Colditz GA, Rimm EB, Willett WCl. Dietary fat intake and risk of
type 2 diabetes in women. Am J Clin Nutr 2001; 73: 1019-26.
King IB, Kristal AR, Schaffer S, Thornquist M, Goodman GE. Serum trans-fatty acids are associated with risk of
prostate cancer in beta-carotene and retinol efficacy trial. Cancer Epidemiol Biomarkers Prev 2005; 14: 988-92.
Rissanen H, Knekt P, Jarvinen R, Salminen I, Hakulinen T. Serum fatty acids and breast cancer incidence. Nutr
Cancer 2003; 45: 168-75.
Babior BM, Kipnes RS, Curnutte JT. Biological defense mechanism. The production by leukocytes of super oxide,
a potential bactericidal agent. J Clin Invest 1973; 52: 741-744.
Hernández-Saavedra D, McCord JM. Evolución y radicales libres. Importancia del estrés oxidativo en la patología
humana. Rev Med Inst Mex Seguro Soc 2007; 45: 477-484.
Murrell GA, Francis MJ, Bromley L. Modulation of fibroblast proliferation by oxygen free radicals. Biochem J.
; 265: 659-65.
Spiteller G. Do changes in the cell membrane structure induce the generation of lipid per oxidation products
which serve as first signaling molecules in cell to cell communication? Prostaglandins Leukot Essent Fatty Acids
; 67: 151-62.
Halliwell B. Antioxidants. En: Ziegler EE, Filer LJ. Present knowledge in nutrition. 7th ed. ILSI Press, Washington
DC, 1996, pp. 596-603.
Ashour MN, Salem SI, El-Gadban HM, Elwan NM, Basu TK. Antioxidant status in children with protein-energy
malnutrition (PEM) living in Cairo, Egypt. Eur J Clin Nutr 1999; 52: 669-673.
Manary MJ, Leeuwenburgh C, Heinecke J. Increased oxidative stress in kwashiorkor. J Pediatr 2000; 137: 421-
Arthur MJ, Bentley IS, Tanner AR, Saunders PK, Millward-Sadler GH, Wright R. Oxygen-derived free radicals
promote hepatic injury in the rat. Gastroenterology 1958; 89: 1114-1122.
Ferrari R, Ceconi C, Curello S, Guarnieri C, Caldarera CM, Albertini A, Visioli O. Oxygen-mediated myocardial
damage during ischemia and reperfusion: role of the cellular defenses against oxygen toxicity. J Mol Cell Cardiol
; 17: 937-945.
Klausner JM, Paterson IS, Kobzik L, Valeri CR, Shepro D, Hechtman HB. Oxygen free radicals mediate ischemiainduced
lung injury. Surgery 1989; 105: 192-199.
Whitehead RG, Alleyne GA. Pathophysiological factors of importance in protein-calorie malnutrition. Brit Med Bull
; 28: 72-79.
Whitehead RG, Coward WA, Lunn PG, Rutishauser I. A comparison of the pathogenesis of protein-energy
malnutrition in Uganda and the Gambia. Trans R Soc Trop Med Hyg 1977; 71: 189-95.
Morlese JF, Forrester T, Jahoor F. Acute-phase protein response to infection in severe malnutrition. Am J
Physiol. 1998; 275(1 Pt 1): E112-7.
Vásquez-Garibay E, Campollo-Rivas O, Romero-Velarde E, Méndez-Estrada C, García-Iglesias T, Alvizo-Mora
JG, Vizmanos-Lamotte B. Effect of renutrition on natural and cell-mediated immune response in infants with
severe malnutrition. J Pediatr Gastroenterol Nutr 2002; 34: 296-301.
Downloads
Additional Files
Published
Issue
Section
License
All accepted originals remain the property of JONNPR. In the event of publication, the authors exclusively transfer their rights of reproduction, distribution, translation and public communication (by any sound, audiovisual or electronic medium or format) of their work. To do so, the authors shall sign a letter transferring these rights when sending the paper via the online manuscript management system.
The articles published in the journal are freely used under the terms of the Creative Commons BY NC SA license, therefore.
You are free to:
Share — copy and redistribute the material in any medium or format
Adapt — remix, transform, and build upon the material
The licensor cannot revoke these freedoms as long as you follow the license terms.
Under the following terms:
Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
NonCommercial — You may not use the material for commercial purposes.
ShareAlike — If you remix, transform, or build upon the material, you must distribute your contributions under the same license as the original.
No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License
