Ningún efecto favorable de la suplementación de cr (III) en el metabolismo de lípidos en Diabetes tipo 2: meta-análisis de ensayos clínicos, simple y doble ciego, controlados con placebo.

  • Ismael San Mauro Martín Research Centers of Nutrition and Health. Paseo de la Habana, 43. 28036, Madrid,
  • Ana María Ruiz León Research Centers of Nutrition and Health. Paseo de la Habana, 43. 28036, Madrid,
  • Elena Garicano Vilar Research Centers of Nutrition and Health. Paseo de la Habana, 43. 28036, Madrid,
  • Luis Collado Yurrita Medicine Department. Universidad Complutense de Madrid. Plaza de Ramón y Cajal. Ciudad Universitaria. 28040, Madrid
  • María José Ciudad Cabañas Medicine Department. Universidad Complutense de Madrid. Plaza de Ramón y Cajal. Ciudad Universitaria. 28040, Madrid
  • Beatriz de Mateo Silleras Department of Nutrition and Food Science. Faculty of Medicine. Universidad de Valladolid. Av. Ramón y Cajal, 7. 47005, Valladolid.
  • María de Paz Redondo del Río Department of Nutrition and Food Science. Faculty of Medicine. Universidad de Valladolid. Av. Ramón y Cajal, 7. 47005, Valladolid.
  • María Alicia Camina Martín Department of Nutrition and Food Science. Faculty of Medicine. Universidad de Valladolid. Av. Ramón y Cajal, 7. 47005, Valladolid.
Palabras clave: Diabetes mellitus tipo II, cromo, suplementación, hiperglucemia.

Resumen

Introducción. Diabetes mellitus tipo II es un importante problema de salud mundial cuya prevalencia ha aumentado en los últimos años. Muchos estudios han relacionado los suplementos de cromo con la mejora de la diabetes mellitus tipo 2.

Objetivo. Realizar un meta-análisis de ensayos individuales y doble ciego, aleatorizados, controlados con placebo, en los que los participantes diagnosticados de DM tipo 2 o intolerantes a la glucosa fueran suplementados con Cr (III).

Métodos. Se llevó a cabo una búsqueda bibliográfica sistemática en bases de datos electrónicas, utilizando los términos de búsqueda: (diabetes) y (cromo), hasta julio de 2016. Los estudios elegibles se limitan a doble o simple ciego, de grupos paralelos,
controlados con placebo, ensayos clínicos aleatorios, comparando la suplementación mono Cr o combinada durante al menos 30 días en comparación con placebo, en sujetos diagnosticados de DM tipo 2 o con intolerancia a la glucosa.

Resultados. La dosis total de la suplementación con Cr y levadura osciló de 20 a 1000 mg / día, y la duración de la administración de suplementos varió de 30 a 120 días. No se encontró reducción estadísticamente significativa en los niveles de HDL-C (p = 0,63), LDL-C (p = 0,53) y TG (p = 0,34) en comparación con el placebo; con un efecto medio ponderado de -0.44 (95% CI: -2.2 to 1.33) mg/dL, - 1.43 (95% CI: -5.94 to 3.08) mg/dL y -7.43 (95% CI: -22.67 to 7.82) mg/dL, respetivamente.

Conclusión. La evidencia de nuestro estudio no sugiere que existen efectos favorables de los suplementos de cromo sobre el control del metabolismo lipídico en pacientes con diabetes tipo II.

 

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Citas

Guariguata L, Whiting DR, Hambleton I, Beagley J, Linnenkamp U, Shaw JE. Global estimates of diabetes prevalence for 2013 and projections for 2035. Diabetes Res Clin Pract. 2014; 103(2):137–49. Available from: http://linkinghub.elsevier.com/retrieve/pii/S0168822713003859

Seuring T, Archangelidi O, Suhrcke M. The Economic Costs of Type 2 Diabetes: A Global Systematic Review. Vol. 33. Springer International Publishing; 2015. p. 811–31.

Dunning T. Overview of complementary and alternative medicine and diabetes. Pract Diabetes. 2014; 31(9):381–6. Available from: http://doi.wiley.com/10.1002/pdi.1908

Penton. Supplement Business Report 2015. Nutr Bus J. 2015; 318.

Scientific Opinion on the risks to public health related to the presence of chromium in food and drinking water. EFSA J. 2014; 12(3):3595. Available from: http://doi.wiley.com/10.2903/j.efsa.2014.3595

Vincent JB. Chromium: Is It Essential, Pharmacologically Relevant, or Toxic? In Springer Netherlands; 2013 [cited 2016 Aug 27]. p. 171–98. Available from: http://link.springer.com/10.1007/978-94-007-7500-8_6

Liu Y, Cotillard A, Vatier C, Bastard J-P, Fellahi S, Stévant M, et al. A Dietary Supplement Containing Cinnamon, Chromium and Carnosine Decreases Fasting Plasma Glucose and Increases Lean Mass in Overweight or Obese Pre-Diabetic Subjects: A Randomized, Placebo-Controlled Trial. PLoS One. 2015; 10(9):e0138646. Available from: http://www.ncbi.nlm.nih.gov/pubmed/26406981

Sharma S, Agrawal RP, Choudhary M, Jain S, Goyal S, Agarwal V. Beneficial effect of chromium supplementation on glucose, HbA1C and lipid variables in individuals with newly onset type-2 diabetes. J Trace Elem Med Biol. 2011; 25(3):149–53. Available from: http://www.ncbi.nlm.nih.gov/pubmed/21570271

Paiva AN, Lima JG de, Medeiros ACQ de, Figueiredo HAO, Andrade RL de, Ururahy MAG, et al. Beneficial effects of oral chromium picolinate supplementation on glycemic control in patients with type 2 diabetes: A randomized clinical study. J Trace Elem Med Biol. 2015; 32:66–72. Available from: http://www.ncbi.nlm.nih.gov/pubmed/26302914

Costello RB, Dwyer JT, Bailey RL, Association AD, Micronutrients I of M (US) P on, Bailey R, et al. Chromium supplements for glycemic control in type 2 diabetes: limited evidence of effectiveness. Nutr Rev. 2016;74(7):455–68. Available from: http://www.ncbi.nlm.nih.gov/pubmed/27261273

Appendix: Jadad Scale for Reporting Randomized Controlled Trials. In: Evidence-based Obstetric Anesthesia [Internet]. Oxford, UK: Blackwell Publishing Ltd; [cited 2016 Jul 24]. p. 237–8. Available from: http://doi.wiley.com/10.1002/9780470988343.app1

Whitehead A, Whitehead J. A general parametric approach to the meta-analysis of randomized clinical trials. Stat Med. 1991; 10(11):1665–77. Available from: http://doi.wiley.com/10.1002/sim.4780101105

DerSimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials. 1986; 7(3):177–88. Available from: http://www.ncbi.nlm.nih.gov/pubmed/3802833

Egger M, Davey Smith G, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ. 1997; 315(7109):629–34. Available from: http://www.ncbi.nlm.nih.gov/pubmed/9310563

Jain SK, Kahlon G, Morehead L, Dhawan R, Lieblong B, Stapleton T, et al. Effect of chromium dinicocysteinate supplementation on circulating levels of insulin, TNF-alfa oxidative stress, and insulin resistance in type 2 diabetic subjects: randomized, double-blind, placebo-controlled study. Mol Nutr Food Res. 2012; 56(8):1333–41. Available from: http://www.ncbi.nlm.nih.gov/pubmed/22674882

Singer GM, Geohas J. The effect of chromium picolinate and biotin supplementation on glycemic control in poorly controlled patients with type 2 diabetes mellitus: a placebo-controlled, double-blinded, randomized trial. Diabetes Technol Ther. 2006; 8(6):636–43. Available from: http://www.ncbi.nlm.nih.gov/pubmed/17109595

Geohas J, Daly A, Juturu V, Finch M, Komorowski JR. Chromium picolinate and biotin combination reduces patherogenic index of plasma in patients with type 2 diabetes mellitus: a placebo-controlled, double-blinded, randomized clinical trial. Am J Med Sci. 2007; 333(3):145–53. Available from: http://www.ncbi.nlm.nih.gov/pubmed/17496732

Guimarães MM, Martins Silva Carvalho AC, Silva MS. Chromium nicotinate has no effect on insulin sensitivity, glycemic control, and lipid profile in subjects with type 2 diabetes. J Am Coll Nutr. 2013; 32(4):243–50. Available from: http://www.ncbi.nlm.nih.gov/pubmed/24024769

Racek J, Trefil L, Rajdl D, Mudrová V, Hunter D, Senft V. Influence of chromium-enriched yeast on blood glucose and insulin variables, blood lipids, and markers of oxidative stress in subjects with type 2 diabetes mellitus. Biol Trace Elem Res. 2006; 109(3):215–30. Available from: http://www.ncbi.nlm.nih.gov/pubmed/16632892

Hosseinzadeh P, Javanbakht MH, Mostafavi S-A, Djalali M, Derakhshanian H, Hajianfar H, et al. Brewer’s Yeast Improves Glycemic Indices in Type 2 Diabetes Mellitus. Int J Prev Med. 2013; 4(10):1131–8. Available from: http://www.ncbi.nlm.nih.gov/pubmed/24319552

Martin J, Wang ZQ, Zhang XH, Wachtel D, Volaufova J, Matthews DE, et al. Chromium picolinate supplementation attenuates body weight gain and increases insulin sensitivity in subjects with type 2 diabetes. Diabetes Care. 2006; 29(8):1826–32. Available from: http://www.ncbi.nlm.nih.gov/pubmed/16873787

Kleefstra N, Houweling ST, Bakker SJL, Verhoeven S, Gans ROB, Meyboom-de Jong B, et al. Chromium treatment has no effect in patients with type 2 diabetes in a Western population: a randomized, double-blind, placebo-controlled trial. Diabetes Care. 2007; 30(5):1092– 6. Available from: http://www.ncbi.nlm.nih.gov/pubmed/17303791

Pei D, Hsieh C-H, Hung Y-J, Li J-C, Lee C-H, Kuo S-W. The influence of chromium chloride-containing milk to glycemic control of patients with type 2 diabetes mellitus: a randomized, double-blind, placebo-controlled trial. Metabolism. 2006; 55(7):923–7. Available from: http://www.ncbi.nlm.nih.gov/pubmed/16784965

Gunton JE, Cheung NW, Hitchman R, Hams G, O’Sullivan C, Foster- Powell K, et al. Chromium supplementation does not improve glucose tolerance, insulin sensitivity, or lipid profile: a randomized, placebo- controlled, doubleblind trial of supplementation in subjects with impaired glucose tolerance. Diabetes Care. 2005; 28(3):712–3. Available from: http://www.ncbi.nlm.nih.gov/pubmed/15735214

Albarracin CA, Fuqua BC, Evans JL, Goldfine ID. Chromium picolinate and biotin combination improves glucose metabolism in treated, uncontrolled overweight to obese patients with type 2 diabetes. Diabetes Metab Res Rev. 2008; 24(1):41–51. Available from: http://www.ncbi.nlm.nih.gov/pubmed/17506119

Kleefstra N, Houweling ST, Jansman FGA, Groenier KH, Gans ROB, Meyboom-de Jong B, et al. Chromium treatment has no effect in patients with poorly controlled, insulin-treated type 2 diabetes in an obese Western population: a randomized, double-blind, placebo- controlled trial. Diabetes Care. 2006; 29(3):521–5. Available from: http://www.ncbi.nlm.nih.gov/pubmed/16505499

San Mauro-Martin I, Ruiz-León AM, Camina-Martín MA, Garicano-Vilar E, Collado-Yurrita L, Mateo-Silleras B de, et al. [Chromium supplementation in patients with type 2 diabetes and high risk of type 2 diabetes: a metaanalysis of randomized controlled trials]. Nutr Hosp. 2016; 33(1):27. Available from: http://www.ncbi.nlm.nih.gov/pubmed/27019254

Yin R V, Phung OJ. Effect of chromium supplementation on glycated hemoglobin and fasting plasma glucose in patients with diabetes mellitus. Nutr J. 2015; 14:14. Available from: http://www.ncbi.nlm.nih.gov/pubmed/25971249

Publicado
2016-12-29