Can gluten contribute to degenerative and neuronal diseases? Still no evidence based results.
DOI:
https://doi.org/10.19230/jonnpr.2016.1.1.918Keywords:
Antigliadin, Autism Spectrum Disorder, Bipolar disorder, Gluten, Neurologic disease, Review, Schizophrenia.Abstract
Introduction: Gluten not only affects humans by causing celiac disease or non- celiac sensibility to gluten, but also contributes to other pathologies associated with glycoproteins. Gluten can cause neurologic damage through a combination of cross-reactive antibodies, complex immune diseases, and direct toxicity.
Aim: The aim of our study is to review scientific literature related to gluten ingestion in neuronal and mental pathologies, and to analyse the evidence that supports this hypothesis. Several search strategies were designed, including PubMed and other scientific databases, and combining keywords according to the study, aiming to the highest-quality scientific evidence possible.
Results: Patients suffering from ataxia, schizophrenia, bipolar disorder, anxiety and mental disorder, or headache due to gluten, have experienced significant relief of their symptoms after being on a gluten-free diet. It has also been suggested that the peptides of both gluten and casein can play a role in the origin of autism. The cause of neurologic symptoms is not known but it has been suggested that the autoimmunity resulting of the molecular mimicry between gliadin and proteins, of the nervous system has a relevant role.
Conclusion: There is a possible association between progressive cognitive deterioration and gluten. Removal of gluten from the diet has improved or stabilized the cognitive condition of studied patients.
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