Neurotoxicity of pesticides. Brief update
DOI:
https://doi.org/10.19230/jonnpr.4824Abstract
Introduction: Pesticides are necessary for the development of today's society, although they pose a risk
to public health, the ecosystem and human health, of people exposed directly and indirectly through the
food chain and / or the environment. . In fact, more and more studies show neurotoxicity derived from
acute and chronic intoxication due to exposure to pesticides.
Method: A brief bibliographic review was carried out on the toxicity of these chemical products, in
relation to the damage they can cause in the nervous system, scientific articles published in English and
Spanish, during the month of May 2022, were examined through the search in the following databases:
Scielo, PubMed, Medline, Springer, Scopus and Science Direct of articles published in English andSpanish, which were published during the period from 2017 to 2022, according to the criteria established
by the PRISMA declaration.
Results: Pesticides are one of the most widely used environmental pollutants and can generate numerous
benefits for humans, however, they are related to neurotoxicity derived from chronic exposure, which
leads to the development of neurodegenerative diseases.
Conclusions: More studies are needed to address the neurotoxicity induced by exposure to pesticides, as
well as to highlight the importance of informing and developing all prevention, control and measures
systems that guarantee the health of the population regarding its potential risk.
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References
Bondareva L, Fedorova N. Pesticides: Behavior in Agricultural Soil and Plants. Molecules. 2021; 26(17):5370. doi: 10.3390/molecules26175370.
Tudi M, Daniel Ruan H, Wang L, Lyu J, Sadler R, Connell D, Chu C, Phung DT. Agriculture Development, Pesticide Application and Its Impact on the Environment. Int J Environ Res Public Health. 2021; 18(3):1112. doi: 10.3390/ijerph18031112.
Aloizou AM, Siokas V, Vogiatzi C, Peristeri E, Docea AO, Petrakis D, Provatas A, Folia V, Chalkia C, Vinceti M, Wilks M, Izotov BN, Tsatsakis A, Bogdanos DP, Dardiotis E. Pesticides, cognitive functions and dementia: A review. Toxicol Lett. 2020; 326:31-51. doi: 10.1016/j.toxlet.2020.03.005
Abreu-Villaça Y, Levin ED. Developmental neurotoxicity of succeeding generations of insecticides. Environ Int. 2017;99:55-77. doi: 10.1016/j.envint.2016.11.019.
Cedillo-Pozos A, Ternovoy SK, Roldan-Valadez E. Imaging methods used in the assessment of environmental disease networks: a brief review for clinicians. Insights Imaging. 2020;11(1):18. doi: 10.1186/s13244-019-0814-7.
Bumb?cil? B, Putz MV. Neurotoxicity of Pesticides: The Roadmap for the Cubic Mode of Action. Curr Med Chem. 2020; 27(1):54-77. doi: 10.2174/0929867326666190704142354.
Pellacani C, Costa LG. Role of autophagy in environmental neurotoxicity. Environ Pollut. 2018; 235:791-805 . doi: 10.1016/j.envpol.2017.12.102.
Hurtado-Barroso S, Tresserra-Rimbau A, Vallverdú-Queralt A, Lamuela-Raventós RM. Organic food and the impact on human health. Crit Rev Food Sci Nutr. 2019; 59(4):704-714.
doi: 10.1080/10408398.2017.1394815.
Adeyemi JA, Ukwenya VO, Arowolo OK, Olise CC. Pesticides-induced Cardiovascular Dysfunctions: Prevalence and Associated Mechanisms. Curr Hypertens Rev. 2021; 17(1):27-34.
doi: 10.2174/1573402117666210111102508.
Chedik L, Bruyere A, Bacle A, Potin S, Le Vée M, Fardel O. Interactions of pesticides with membrane drug transporters: implications for toxicokinetics and toxicity. Expert Opin Drug Metab Toxicol.
; 14(7):739-752. Doi: 10.1080/17425255.2018.1487398.
Xu S, Yang X, Qian Y, Luo Q, Song Y, Xiao Q. Analysis of serum levels of organochlorine pesticides and related factors in Parkinson's disease. Neurotoxicology. 2022:216-223.
doi: 10.1016/j.neuro.2021.12.001
Narayan S, Liew Z, Bronstein JM, Ritz B. Occupational pesticide use and Parkinson's disease in the Parkinson Environment Gene (PEG) study. Environ Int. 2017; 107:266-273.
doi: 10.1016/j.envint.2017.04.010.
Medehouenou TCM, Ayotte P, Carmichael PH, Kröger E, Verreault R, Lindsay J, Dewailly É, Tyas SL, Bureau A, Laurin D. Exposure to polychlorinated biphenyls and organochlorine pesticides and risk of dementia, Alzheimer's disease and cognitive decline in an older population: a prospective analysis from the Canadian Study of Health and Aging. Environ Health. 2019; 18(1):57.
doi: 10.1186/s12940-019-0494-2.
Banba S. Application of computational methods in the analysis of pesticide target-site and resistance mechanisms. J Pestic Sci. 2021;46(3):283-289. doi: 10.1584/jpestics.J21-01
Gezer AO, Kochmanski J, VanOeveren SE, Cole-Strauss A, Kemp CJ, Patterson JR, Miller KM, Kuhn NC, Herman DE, McIntire A, Lipton JW, Luk KC, Fleming SM, Sortwell CE, Bernstein AI. Developmental exposure to the organochlorine pesticide dieldrin causes male-specific exacerbation of ?-synuclein-preformed fibril-induced toxicity and motor deficits. Neurobiol Dis. 2020; 141:104947. doi: 10.1016/j.nbd.2020.104947.
Russo M, Sobh A, Zhang P, Loguinov A, Tagmount A, Vulpe CD, Liu B. Functional Pathway Identification With CRISPR/Cas9 Genome-wide Gene Disruption in Human Dopaminergic Neuronal Cells Following Chronic Treatment With Dieldrin. Toxicol Sci. 2020;176(2):366-381.
doi: 10.1093/toxsci/kfaa07
Schmidt JT, Rushin A, Boyda J, Souders CL 2nd, Martyniuk CJ. Dieldrin-induced neurotoxicity involves impaired mitochondrial bioenergetics and an endoplasmic reticulum stress response in rat dopaminergic cells. Neurotoxicology. 2017; 63:1-12. doi: 10.1016/j.neuro.2017.08.007.
Bhattu M, Verma M, Kathuria D. Recent advancements in the detection of organophosphate pesticides: a review. Anal Methods. 2021;13(38):4390-4428. doi: 10.1039/d1ay01186c.
Zhang HY, Wang C, Li HS. [Effect of organophosphate pesticides poisoning on cognitive impairment]. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2021;39(4):313-316. Chinese.
doi: 10.3760/cma.j.cn121094-20200325-00161.
Rossetti MF, Stoker C, Ramos JG. Agrochemicals and neurogenesis. Mol Cell Endocrinol. 2020; 510:110820. doi: 10.1016/j.mce.2020.110820.
Pereira PCG, Parente CET, Carvalho GO, Torres JPM, Meire RO, Dorneles PR, Malm O. A review on pesticides in flower production: A push to reduce human exposure and environmental contamination. Environ Pollut. 2021; 289:117817. doi: 10.1016/j.envpol.2021.117817.
Ho?y?ska-Iwan I, Szewczyk-Golec K. Pyrethroids: How They Affect Human and Animal Health? Medicina (Kaunas). 2020 Oct 30;56(11):582. doi: 10.3390/medicina56110582.
Richardson JR, Fitsanakis V, Westerink RHS, Kanthasamy AG. Neurotoxicity of pesticides. Acta Neuropathol. 2019; 138(3):343-362. doi: 10.1007/s00401-019-02033-9.
Peillex C, Pelletier M. The impact and toxicity of glyphosate and glyphosate-based herbicides on health and immunity. J Immunotoxicol. 2020; 17(1):163-174. doi: 10.1080/1547691X.2020.1804492
Weed DL. Does paraquat cause Parkinson's disease? A review of reviews. Neurotoxicology. 2021; 86:180-184. doi: 10.1016/j.neuro.2021.08.006.
Rondeau S, Raine NE. Fungicides and bees: a review of exposure and risk. Environ Int. 2022; 165:107311. doi: 10.1016/j.envint.2022.107311.
Matassini C, Parmeggiani C, Cardona F. New Frontiers on Human Safe Insecticides and Fungicides: An Opinion on Trehalase Inhibitors. Molecules. 2020;25(13):3013. doi: 10.3390/molecules25133013.
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