Assessment of the Treatment of Bruxism by botulinum toxin

Authors

  • Ana Belén Marcos Navarro Alumnos Especialista Universitario en Dolor Universidad de Castilla la Mancha. España
  • Mario Romero de Ávila Pediatra de Hospital de Almansa. España
  • Loreto Tarraga Marcos Enfermera Materno infantil del Hospital Clinico Lozano Blesa de Zaragoza. España
  • Fatima Madrona Marcos Médico residente de Medicina de Familia. EAP Zona 5 de Albacete. España
  • Pedro J. Tarraga López Profesor de Medicina de Universidad de Castilla la Mancha. España

DOI:

https://doi.org/10.19230/jonnpr.4064

Keywords:

bruxism; Botulinum toxin; Quality of life

Abstract

Bruxism is characterized by being an activity related to the activation of the chewing muscles repeatedly and usually during sleep. The relevance of this entity resides in its association with tooth erosions and mobility, dental fractures, myalgia and hypertrophy of the masseter muscle and or characteristic arthralgia. Although its etiology is not clear, it is related to a multitude of pathophysiological factors. Currently there are many lines of treatment for this health problem, such as: cognitive-behavioral therapy, occlusion or discharge splints, pharmacological options such as benzodiazepines, and dopamine. These measures usually serve to manage the signs and symptoms derived from bruxism, but the effectiveness of all of them is not total.

Currently, faced with the need to search for other therapeutic options for the problem of bruxism, multiple trials have focused their attention on the use of botulinum toxin as an alternative, taking into account its efficacy for a wide variety of medical and aesthetic pathologies.

The objective of this update is to update the knowledge to date of the existing evidence about the use of botulinum toxin in the treatment of bruxism. For this, the existing systematic reviews that include the main available randomized clinical trials are selected.

Method. Bibliographic review in the main databases using the words "bruxism" and / or "botulinum toxin"

Results. After the analysis of the different reviews we can say that all the results point in the same direction: that botulinum toxin injections in the masseter and / or temporal muscles can be a valid treatment option in patients with bruxism, since they can improve the quality of life. With the exception of the systematic review by Ågren et al, 28 who do not see evidence through the tests that record electromyographic activity and bite force to recommend the use of botulinum toxin as a treatment for bruxism at the present time.

Conclusions. botulinum toxin infiltrations can reduce the frequency of bruxism episodes, as well as the chewing force, and reduce pain levels derived from it, which translates into an improvement in the quality of life of patients, with a low percentage of side effects.

 

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References

American Academy of Sleep Medicine. International Classification of Sleep Disorders: Diagnostic and Coding Manual, 3rd ed, American Academy of Sleep Medicine, Westchester, IL 2014.

Lobbezoo F, Ahlberg J, Glaros AG, et al. Bruxism defined and graded: an international consensus. J Oral Rehabil 2013; 40:2.

Manfredini D, Winocur E, Guarda-Nardini L, Paesani D, Lobbezoo F. Epidemiology of bruxism in adults: A systematic review of the literature. J Orofac Pain. 2013; 27:99–110.

Ohayon MM, Li KK, Guilleminault C. Risk factors for sleep bruxism in the general population. Chest 2001; 119:53.

Laberge L, Tremblay RE, Vitaro F, Montplaisir J. Development of parasomnias from childhood to early adolescence. Pediatrics 2000; 106:67.

Cheifetz AT, Osganian SK, Allred EN, Needleman HL. Prevalence of bruxism and associated correlates in children as reported by parents. J Dent Child (Chic) 2005; 72:67.

Petit D, Touchette E, Tremblay RE, et al. Dyssomnias and parasomnias in early childhood. Pediatrics 2007; 119:e1016.

Lavigne GJ, Montplaisir JY. Restless legs syndrome and sleep bruxism: prevalence and association among Canadians. Sleep 1994; 17:739.

Lavigne G, Manzini C, Kato T. Sleep bruxism. In: Principles and Practice of Sleep Medicine, 4th ed, Kryger MH, Roth T, Dement WC (Eds), Saunders, Philadelphia 2005. p.946.

Rompré PH, Daigle-Landry D, Guitard F, et al. Identification of a sleep bruxism subgroup with a higher risk of pain. J Dent Res 2007; 86:837.

Hesselbacher S, Subramanian S, Rao S, et al. Self-reported sleep bruxism and nocturnal gastroesophageal reflux disease in patients with obstructive sleep apnea: relationship to gender and ethnicity. Open Respir Med J 2014; 8:34.

Magnusson T, Egermarki I, Carlsson GE. A prospective investigation over two decades on signs and symptoms of temporomandibular disorders and associated variables. A final summary. Acta Odontol Scand 2005; 63:99.

Huynh N, Guilleminault C. Sleep bruxism in children. In: Sleep Medicine for Dentists, Lavigne GJ, Cistuilli PA, Smith MT (Eds), Quintessence, Chicago 2009. p.125.

Lavigne GJ, Huynh N, Kato T, et al. Genesis of sleep bruxism: motor and autonomic-cardiac interactions. Arch Oral Biol 2007; 52:381.

Macedo CR, Silva AB, Machado MA, et al. Occlusal splints for treating sleep bruxism (tooth grinding). Cochrane Database Syst Rev 2007; :CD005514.

Hachul H, Bittencourt LR, Andersen ML, et al. Effects of hormone therapy with estrogen and/or progesterone on sleep pattern in postmenopausal women. Int J Gynaecol Obstet 2008; 103:207.

Tan EK, Jankovic J. Treating severe bruxism with botulinum toxin. J Am Dent Assoc 2000; 131:211.

Alonso-Navarro H, Jiménez-Jiménez FJ, Plaza-Nieto JF, et al. [Treatment of severe bruxism with botulinum toxin type A]. Rev Neurol 2011; 53:73.

Ivanhoe CB, Lai JM, Francisco GE. Bruxism after brain injury: successful treatment with botulinum toxin-A. Arch Phys Med Rehabil 1997; 78:1272.

Tinastepe N, Küçük BB, Oral K. Botulinum toxin for the treatment of bruxism. Cranio 2015; 33:291.

Shim YJ, Lee MK, Kato T, et al. Effects of botulinum toxin on jaw motor events during sleep in sleep bruxism patients: a polysomnographic evaluation. J Clin Sleep Med 2014; 10:291.

De la Torre Canales G, Câmara-Souza MB, do Amaral CF, ¿et al. Is there enough evidence to use botulinum toxin injections for bruxism management? A systematic literature review. Clin Oral Investig 2017; 21:727.

Ondo WG, Simmons JH, Shahid MH, et al. Onabotulinum toxin-A injections for sleep bruxism: A double-blind, placebo-controlled study. Neurology 2018; 90:e559.

Nash MC, Ferrell RB, Lombardo MA, Williams RB. Treatment of bruxism in Huntington's disease with botulinum toxin. J Neuropsychiatry Clin Neurosci 2004; 16:381.

Manfredini, D., Ahlberg, J., Winocur, E. and Lobbezoo, F. Management of sleep bruxism in adults: a qualitative systematic literature review. Journal of Oral Rehabilitation, 2015; 42(11), pp.862-874.

Patel J, Cardoso J, Mehta S. A systematic review of botulinum toxin in the management of patients with temporomandibular disorders and bruxism. British Dental Journal. 2019;226(9):667-672.

Fernandez-Nunez T, Amghar-Maach S, Gay-Escoda C. Efficacy of botulinum toxin in the treatment of bruxism: Systematic review. Medicina Oral Patología Oral y Cirugia Bucal. 2019;:0-0.

Ågren M, Sahin C, Pettersson M. T he effect of botulinum toxin injections on bruxism: A systematic review. Journal of Oral Rehabilitation. 2019;47(3):395-402.

Sendra L, Montez C, Vianna K, Barboza E. Clinical outcomes of botulinum toxin type A injections in the management of primary bruxism in adults: A systematic review. The Journal of Prosthetic Dentistry. 2020

Published

2021-09-07