Noggin's role in obesity: Biomarker potential?
DOI:
https://doi.org/10.19230/jonnpr.3821Keywords:
Noggin, obesity, overweight, adipogenesisAbstract
Obesity is a multifactorial disease resulting from the interaction between genetic, behavioral and environmental factors that can influence the individual response to eating and exercise habits. Its prevalence has increased drastically in the last decade, becoming a public health problem because is associated with diseases such as type II diabetes, cardiovascular damage, hyperlipidemias and cancer, which affect both sexes, all ages and all ethnic groups. Currently, it is the most prevalent metabolic disease in developed countries.
There are many loci and several genes that have been associated with the predisposition for obesity and thinness, obesity development and classified according to their expression in different stages of this condition, such as in early onset, predisposition to obesity, late onset, severe obesity (morbid).
In this article I review the potential role of the Noggin gene in adipogenesis and the possible mechanisms or signaling pathways in which this gene intervenes to lead to obesity.
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