Phylogeography of glmM in Helicobacter pylori strains isolated from patients with gastric pathologies in southern Mexico
DOI:
https://doi.org/10.19230/jonnpr.3769Keywords:
Helicobacter pylori, genetic variability, glmM gene, phylogeographyAbstract
Introduction: Helicobacter pylori has a genome of approximately 1600 genes, the glmM gene is highly conserved and has been identified to identify H. pylori due to its sensitivity and specificity in gastric biopsies. The genetic diversity of H. pylori is high among strains of the same geographical origin and is even more of a global scale. In Mexico, studies that study the importance of the genetic variability of this bacterium, which is studied by molecular techniques.
Aim. To analyze the genetic variability of the glmM genus in H pylori strains of patients with gastric pathologies.
Methodology. Only 90 sequences of the glmM genus were analyzed (10 of study group and 80 deposit in GenBank), to carry out haplotype networks, where the differences in the steps of the relationships at the state level and with other geographical groups can be observed in order to do a reconstruction of phylogeny based on ancestor-descendant relationships.
Results. The strains analyzed showed 30% of men and 70% of women, with an average age of 42 years, diagnosed with gastritis, the glmM sequences. From the sequences analyzed, it is proposed to confirm the presence of eight haplotypes that are grouped separately.
Conclusions. We suggest university studies at the molecular level of the glmM haplotypes in strains of H. pylori to know their geographical distribution in order to know the circulating strains worldwide and with this avoid negative results.
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