Can I diagnose hypoglycemia in domestic ferrets (Mustela putorius furo) with the use of portable glucometers?
DOI:
https://doi.org/10.19230/jonnpr.3620Keywords:
hypoglycemia, insulinoma, glucometerAbstract
Aims. The diagnosis of hypoglycemia in ferrets (Mustela putorius furo) is based on the detection of a blood glucose level below 60-70 mg / dl. A blood glucose concentration below these levels is very suggestive of pancreatic beta cell tumor (insulinoma), which comprises of approximately 25% of all neoplasms diagnosed in this species. This study aims to check if the low blood glucose values obtained through the use of portable glucometers are reliable as a method of diagnosing hypoglycemia in this species.
Material and methods. In this study, 31 samples of ferrets blood of different ages and sexes are analyzed, using three types of portable glucometers, comparing these results with the measurements obtained by a liquid biochemistry analyzer using the glucose oxidase method, considered as one of the standard measurement methods.
Results. One of the three glucometers used in this study underestimates blood glucose values in this species, while another overestimates them, which is a systematic error (predictable) of the equipment that could be solved by calibrating them for this species. The other glucometer is more consistent with the reference values, but has a high random error (unpredictable), that is more difficult to correct. Therefore none of the three teams would be adequate to make a reliable diagnosis of hypoglycemia in ferrets.
Conclusions. These results indicate that blood glucose concentrations in ferrets should be confirmed with a validated laboratory analyzer to reliably diagnose hypoglycemia, and blood glucose meters used only to monitor the disease.
Downloads
References
Di Girolamo N, Selleri P. Medical and Surgical Emergencies in Ferrets. Veterinary Clinics of North America: Exotic Animal Practice. Volume 19, Issue 2, May 2016, Pages 431–464.
Petritz OA, Antinoff N, Chen S, Kass PH, Paul-Murphy JR. Evaluation of portable blood glucose meters for measurement of blood glucose concentration in ferrets (Mustela putorius furo). JAVMA, Vol 242, No. 3, February 1, 2013: 350- 354.
Gómez Pizano DA , Rodríguez Hernández A , Ducoing Watty AM , Castillo Mata DA , Maldonado Reséndiz RI. Medición de glicemia en hurones: evaluación de tres métodos portátiles de uso humano. Journal of negative and no positive results, 2019, 4 (8): 785-795. DOI: 10.19230/jonnpr.3044
Sacks DB. Carbohydrates. In: Burtis CA, Ashwood ER, Bruns DE, eds. Tietz textbook of clinical chemistry and molecular diagnostics. 5th ed. St. Louis: Elsevier Saunders, 2012.
Miller WG, Myers GL, Ashwood ER, Killeen AA, Wang E, Ehlers GW, et al. State of the art in trueness and interlaboratory harmonization for 10 analytes in general clinical chemistry. Arch Pathol Lab Med 2008; 132: 838- 46.
Carrasco JL y Jover L. Métodos estadísticos para evaluar la concordancia. Med Clin (Barc) 2004;122(Supl 1):28- 34.
Published
Issue
Section
License
All accepted originals remain the property of JONNPR. In the event of publication, the authors exclusively transfer their rights of reproduction, distribution, translation and public communication (by any sound, audiovisual or electronic medium or format) of their work. To do so, the authors shall sign a letter transferring these rights when sending the paper via the online manuscript management system.
The articles published in the journal are freely used under the terms of the Creative Commons BY NC SA license, therefore.
You are free to:
Share — copy and redistribute the material in any medium or format
Adapt — remix, transform, and build upon the material
The licensor cannot revoke these freedoms as long as you follow the license terms.
Under the following terms:
Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
NonCommercial — You may not use the material for commercial purposes.
ShareAlike — If you remix, transform, or build upon the material, you must distribute your contributions under the same license as the original.
No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License
