Case series study: Low-histamine diet treatment to two patients with migraine and diamine oxidase deficiency
DOI:
https://doi.org/10.19230/jonnpr.3036Keywords:
Histamine, diamine oxidase (DAO), migraine, low-histamine diet, histamine intoleranceAbstract
Introduction & aims: Deficiency of Diamine Oxidase (DAO) enzyme, the main enzyme responsible for histamine-food metabolism, is being used as a new diagnosis to justify the appearance of different clinical symptoms, such as migraine, urticaria or some digestive disorders, among others. All of them could be related to the intake of histamine-rich food. The aim in both cases was to assess the efficacy of a lowhistamine diet in two patients with migraine and DAO deficiency.
Material and methods: The two case study involves the follow-up of a 39-year-old woman and a 49- yearold woman. Both of them diagnosed with migraine that did not improve following the usual medical treatment prescribed by the doctor. Therefore, DAO activity was analysed after realizing that DAO deficiency could be related to other symptoms that they presented. Due to the results obtained, it was necessary to follow a dietary treatment with a low-histamine healthy diet and exogenous DAO enzyme supplementation.
Results: After some weeks following the dietary treatment, the first case began to notice improvement in neurological symptoms. After months of follow-up she has improved not only the migraine and headache, but also respiratory, digestive and fatigue symptoms. On the other hand, in the second case, it seems to be a little improvement but migraine episodes continue almost as in the beginning.
Conclusions: A low-histamine diet supplemented with exogenous DAO enzyme should be considerate as a new management in patients with migraine and DAO deficiency.
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References
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