Is sleep apnea-hypopnea syndrome a new cardiovascular risk factor? A literature review that does not confirm it

Authors

  • Mª Dolores Gómez Olivares Facultad de Medicina. Universidad Castilla la Mancha.
  • Pedro Juan Tárraga López Universidad Castilla la Mancha. Medico Familia EAP zona 5A. Albacete.
  • Ibrahim M. Sadek Médico Residente EAP Zona 5A. Albacete.
  • Fátima Madrona Marcos Médico Residente EAP Zona 5A. Albacete.

DOI:

https://doi.org/10.19230/jonnpr.1590

Keywords:

Sleep-disordered-breathing, Cardiovascular disease, Cerebrovascular disease, Hypertension, Adults

Abstract

Introduction: The factors that favor and can trigger cardiovascular diseases are of great interest given their high morbidity and mortality in the population. In this paper, a literature review is carried out to verify whether sleep apnea-hypopnea syndrome (SAHS) acts as a risk factor for cardiovascular diseases in adults. It is important to show if there is a correlation because sleep apneas are very prevalent in the population, increase with age and their diagnosis and treatment are simple.

Objectives: To verify if SAHS is a cardiovascular risk factor in adults.

Results: The association of SAHS with hypertension, cerebrovascular, cardiovascular, arrhythmia and sudden death in adults has been studied. It has been shown that apneas act as a risk factor independently for these pathologies and that CPAP treatment improves the clinical and decreases the risk of mortality from cardiovascular diseases.

Conclusions: Although an abnormal respiratory pattern predisposes to cardiovascular disease, SAHS is not confirmed as a cardiovascular risk factor

 

Downloads

Download data is not yet available.

References

Lloberes P, Durán-Cantolla J, Martínez-García MÁ, Marín JM, Ferrer A, Corral J, et al. Diagnóstico y tratamiento del síndrome de apneas- hipopneas del sueño. Arch Bronconeumol. 1 de marzo de 2011;47(3):143-56.

Parra-Ordaz O. Riesgo cardiovascular en el síndrome de apnea- hipopnea del sueño. Arch Bronconeumol. 30 de diciembre de 2005;41:30- 5.

Torre-Bouscoulet L, Meza-Vargas MS, Castorena-Maldonado A, Pérez- Padilla R. Riesgo cardiovascular en adultos con síndrome de apnea obstructiva del sueño. A 25 años de los primeros estudios de asociación. Gac Med Mex. 2008;144(4):323-32.

Arzt M, Young T, Finn L, Skatrud JB, Bradley TD. Association of Sleep- disordered Breathing and the Occurrence of Stroke. Am J Respir Crit Care Med. 1 de diciembre de 2005;172(11):1447-51.

Peppard PE, Young T, Palta M, Skatrud J. Prospective Study of the Association between Sleep-Disordered Breathing and Hypertension. New England Journal of Medicine. 11 de mayo de 2000;342(19):1378-84.

Martínez-García MÁ, Amilibia J, Chiner E, Queipo C, Atauri D de, Josefa M, et al. Apnea del sueño en individuos de edad avanzada. Actividad asistencial (2002–2008) en España. Arch Bronconeumol. 1 de octubre de 2010;46(10):502-7.

Cascaes da Silva F, Arancibia V, Angélica B, da Rosa Iop R, Filho BG, Jose P, et al. Escalas y listas de evaluación de la calidad de estudios científicos. Revista Cubana de Información en Ciencias de la Salud. Septiembre de 2013;24(3):295-312.

Chiner, E, Arriero, J. M, Signes-Costa, J, Marco, J, Fuentes, I. Validación de la versión española del test de somnolencia Epworth en pacientes con síndrome de apnea de sueño. . Archivos de Bronconeumología.2000;35(9): 422-427.

Mediano San Andrés.O, Gómez Falguera.S, Torres Cortada.G, Barbé Illa.F. Síndrome de apneas del sueño y riesgo cardiovascular. Revista de Patología respiratoria. 2007;149-155.

Gami AS, Howard DE, Olson EJ, Somers VK. Day–Night Pattern of Sudden Death in Obstructive Sleep Apnea. New England Journal of Medicine. 24 de marzo de 2005;352(12):1206-14.

Haas DC, Foster GL, Nieto FJ, Redline S, Resnick HE, Robbins JA, et al. Age-Dependent Associations Between Sleep-Disordered Breathing and Hypertension: Importance of Discriminating Between Systolic/Diastolic Hypertension and Isolated Systolic Hypertension in the Sleep Heart Health Study. Circulation. 8 de febrero de 2005;111(5):614-21.

Redline S, Yenokyan G, Gottlieb DJ, Shahar E, O’Connor GT, Resnick HE, et al. Obstructive Sleep Apnea–Hypopnea and Incident Stroke. Am J Respir Crit Care Med. 15 de julio de 2010;182(2):269-77.

Yaggi HK, Concato J, Kernan WN, Lichtman JH, Brass LM, Mohsenin V. Obstructive Sleep Apnea as a Risk Factor for Stroke and Death. N Engl J Med. 10 de noviembre de 2005;353(19):2034-41

Shahar E, Whitney CW, Redline S, Lee ET, Newman AB, Nieto FJ, et al. Sleep-disordered breathing and cardiovascular disease: cross-sectional results of the Sleep Heart Health Study. Am J Respir Crit Care Med. enero de 2001;163(1):19-25.

Marin JM, Carrizo SJ, Vicente E, Agusti AGN. Long-term cardiovascular outcomes in men with obstructive sleep apnoea- hypopnoea with or without treatment with continuous positive airway pressure: an observational study. Lancet. 19 de marzo de 2005;365(9464):1046-53.

Peker Y, Carlson J, Hedner J. Increased incidence of coronary artery disease in sleep apnoea: a long-term follow-up. European Respiratory Journal. 1 de septiembre de 2006;28(3):596-602.

Gottlieb DJ, Yenokyan G, Newman AB, O’Connor GT, Punjabi NM, Quan SF, et al. A Prospective Study of Obstructive Sleep Apnea and Incident Coronary Heart Disease and Heart Failure: The Sleep Heart Health Study. Circulation. 27 de julio de 2010;122(4):352-60.

Mehra R, Benjamin EJ, Shahar E, Gottlieb DJ, Nawabit R, Kirchner HL, et al. Association of Nocturnal Arrhythmias with Sleep-disordered Breathing. Am J Respir Crit Care Med. 15 de abril de 2006;173(8):910-6.

Mooe T, Franklin KA, Holmström K, Rabben T, Wiklund U. Sleep- disordered Breathing and Coronary Artery Disease. Am J Respir Crit Care Med. 15 de noviembre de 2001;164(10):1910-3.

Terán Santos J, Álvarez A, Luz M, Cordero Guevara J, Azcárate A, María J, et al. Síndrome de apneashipopneas durante el sueño y corazón. Rev Esp Cardiol. 1 de julio de 2006;59(07):718-24.

Published

2017-09-06