Noggin's role in obesity: Biomarker potential?

Maria Luz Gunturiz Albarracín

doi:10.19230/jonnpr.3821

Autores/as

Maria Luz Gunturiz Albarracín Project Bank Team, Public Health Research Division, National Institute of Health. Avenue Street 26 No 51-20 CAN, Bogotá, D.C., Colombia

DOI:

https://doi.org/10.19230/jonnpr.3821

Palabras clave:

Nogina, obesidad, sobrepeso, adipogénesis

Resumen

La obesidad es una enfermedad multifactorial resultado de la interacción entre factores genéticos, conductuales y ambientales que pueden influir en la respuesta individual a los hábitos alimenticios y de ejercicio físico. Su prevalencia ha aumentado dramáticamente durante la última década convirtiéndose en un problema de salud pública porque se asocia a patologías como diabetes tipo II, daño cardiovascular, hiperlipidemias y cáncer, que afectan a ambos sexos, todas las edades y todos los grupos étnicos. Actualmente, es la enfermedad metabólica más prevalente en los países desarrollados.
Hay muchos loci y varios genes que se han asociado con la predisposición a la obesidad, a la delgadez, y al desarrollo de la obesidad y se clasifican según su expresión en diferentes etapas de esta condición, como inicio temprano, predisposición a la obesidad, inicio tardío, obesidad severa (mórbida).
En este artículo se revisa el papel potencial del gen Nogina en la adipogénesis y los posibles mecanismos o vías de señalización en los que este gen interviene para conducir a la obesidad.

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