¿Es la inclusión de datos de Ensayos Controlados Aleatorizados en las guías clínicas suficiente para la mejor práctica basada en la evidencia?

  • Ismael San Mauro Martin Research Centers in Nutrition and Health. Madrid, Spain
  • Elena Garicano Vilar Research Centers in Nutrition and Health. Madrid, Spain




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Gisbert JP, Alonso-Coello P, Piqué JM. ¿Cómo localizar, elaborar, evaluar y utilizar guías de práctica clínica? Gastroenterol Hepatol. 2008;31(4):239–57.

Virginia Commonwealth University. Nursing Evidence Based Practice Resources [Internet]. VCU Libraries Research Guides. 2019 [cited 2019 Sep 27]. Available from: https://guides.library.vcu.edu/ebpsteps/evidencesummaries

Cabana MD, Rand CS, Powe NR, Wu AW, Wilson MH, Abboud PAC, et al. Why don’t physicians follow clinical practice guidelines?: A framework for improvement. J Am Med Assoc. 1999;282:1458–65.

Poblano-Verástegui O, Vieyra-Romero WI, Galván-García ÁF, Fernández-Elorriaga M, Rodríguez-Martínez AI, Saturno-Hernández PJ. Calidad y cumplimiento de guías de práctica clínica de enfermedades crónicas no transmisibles en el primer nivel. Salud Publica Mex. 2017;59(2):165–75.

Harbour R, Miller J. A new system for grading recommendations in evidence based guidelines. Br Med J. 2001;323:334–6.

Grading of Recommendations Assessment Development and Evaluation working group. GRADE [Internet]. [cited 2019 Sep 13]. Available from: http://www.gradeworkinggroup.org/

Oxman AD. Grading quality of evidence and strength of recommendations. Br Med J. 2004;328(7454):1490.

Aymerich M, Sánchez E. From scientific knowledge of clinical research to the bedside: clinical practice guidelines and their implementation. Gac Sanit. 2004;18:326–34.

GetReal. Real-World Evidence in Medicine Development [Internet]. 2017 [cited 2019 Sep 27]. Available from: https://www.imi-getreal.eu/News/ID/85/GetReal-online-course-Real-World-Evidence-in-Medicine-Development- -2-Oct--12-Nov-2017

Blonde L, Khunti K, Harris SB, Meizinger C, Skolnik NS. Interpretation and Impact of Real-World Clinical Data for the Practicing Clinician. Adv Ther. 2018;35(11):1763–1774.

Kim HS, Lee S, Kim JH. Real-world evidence versus randomized controlled trial: Clinical research based on electronic medical records. J Korean Med Sci.2018;33(34):e213.

Katkade VB, Sanders KN, Zou KH. Real world data: An opportunity to supplement existing evidence for the use of long-established medicines in health care decision making. J Multidiscip Healthc. 2018;11:295–304.

Khosla S, White R, Medina J, Ouwens M, Emmas C, Koder T, et al. Real world evidence (RWE) - a disruptive innovation or the quiet evolution of medical evidence generation? [version 1; referees: 2 approved]. F1000Research. 2018;7:111.

Zarbin M. Real Life Outcomes vs. Clinical Trial Results. J Ophthalmic Vis Res. 2019;14(1):88–92.

Fortin M, Dionne J, Pinho G, Gignac J, Almirall J, Lapointe L. Randomized controlled trials: Do they have external validity for patients with multiple comorbidities? Ann Fam Med. 2006;4(2):104–8.

Kim HS, Kim JH. Proceed with caution when using real world data and real world evidence. J Korean Med Sci. 2019;34(4):e28.

Graham S, McDonald L, Wasiak R, Lees M, Ramagopalan S. Time to really share realworld data? F1000Research. 2018;7:1054.

Azam A. Real World Evidence - Does it influence prescribing decisions? [Internet]. MD Analytics. 2018 [cited 2019 Sep 27]. Available from: https://www.mdanalytics.com/2019/05/28/real-world-evidence-infographic/